Recommendations for management of patients with neuroendocrine liver metastases

Andrea Frilling, Irvin M. Modlin*, Mark Kidd, Christopher Russell, Stefan Breitenstein, Riad Salem, Dik Kwekkeboom, Wan yee Lau, Catherine Klersy, Valerie Vilgrain, Brian Davidson, Mark Siegler, Martyn Caplin, Enrico Solcia, Richard Schilsky

*Corresponding author for this work

Research output: Contribution to journalReview article

238 Scopus citations

Abstract

Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or targeted agents. A paucity of biological, molecular, and genomic information and an absence of data from rigorous trials limit the validity of many publications detailing management. This Review represents the views from an international conference, for which 15 expert working groups prepared evidence-based assessments addressing specific questions, and from which an independent jury derived final recommendations. The aim of the conference was to review the existing approaches to neuroendocrine liver metastases, assess the evidence on which management decisions were based, develop internationally acceptable recommendations for clinical practice (when evidence was available), and make recommendations for clinical and research endeavours. This report represents the final clinical statements and proposals for future research.

Original languageEnglish (US)
Pages (from-to)e8-e21
JournalThe Lancet Oncology
Volume15
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Oncology

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    Frilling, A., Modlin, I. M., Kidd, M., Russell, C., Breitenstein, S., Salem, R., Kwekkeboom, D., Lau, W. Y., Klersy, C., Vilgrain, V., Davidson, B., Siegler, M., Caplin, M., Solcia, E., & Schilsky, R. (2014). Recommendations for management of patients with neuroendocrine liver metastases. The Lancet Oncology, 15(1), e8-e21. https://doi.org/10.1016/S1470-2045(13)70362-0