Recommended patient-reported core set of symptoms and quality-of-life domains to measure in ovarian cancer treatment trials

Kristine A. Donovan, Heidi S. Donovan, David Cella, Martha E. Gaines, Richard T. Penson, Steven C. Plaxe, Vivian E. Von Gruenigen, Deborah Watkins Bruner, Bryce B. Reeve, Lari Wenzel*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

There is no consensus as to what symptoms or quality-of-life (QOL) domains should be measured as patient-reported outcomes (PROs) in ovarian cancer clinical trials. A panel of experts convened by the National Cancer Institute reviewed studies published between January 2000 and August 2011. The results were included in and combined with an expert consensus-building process to identify the most salient PROs for ovarian cancer clinical trials. We identified a set of PROs specific to ovarian cancer: abdominal pain, bloating, cramping, fear of recurrence/disease progression, indigestion, sexual dysfunction, vomiting, weight gain, and weight loss. Additional PROs identified in parallel with a group charged with identifying the most important PROs across cancer types were anorexia, cognitive problems, constipation, diarrhea, dyspnea, fatigue, nausea, neuropathy, pain, and insomnia. Physical and emotional domains were considered to be the most salient domains of QOL. Findings of the review and consensus process provide good support for use of these ovarian cancer-specific PROs in ovarian cancer clinical trials.

Original languageEnglish (US)
Article numberdju128
JournalJournal of the National Cancer Institute
Volume106
Issue number7
DOIs
StatePublished - Jul 9 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Donovan, K. A., Donovan, H. S., Cella, D., Gaines, M. E., Penson, R. T., Plaxe, S. C., Von Gruenigen, V. E., Bruner, D. W., Reeve, B. B., & Wenzel, L. (2014). Recommended patient-reported core set of symptoms and quality-of-life domains to measure in ovarian cancer treatment trials. Journal of the National Cancer Institute, 106(7), [dju128]. https://doi.org/10.1093/jnci/dju128