Recovery of drug-resistant influenza virus from immunocompromised patients: A case series

Michael G. Ison, Larisa V. Gubareva, Robert L. Atmar, John Treanor, Frederick G. Hayden*

*Corresponding author for this work

Research output: Contribution to journalArticle

209 Scopus citations

Abstract

Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.

Original languageEnglish (US)
Pages (from-to)760-764
Number of pages5
JournalJournal of Infectious Diseases
Volume193
Issue number6
DOIs
StatePublished - Mar 15 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Recovery of drug-resistant influenza virus from immunocompromised patients: A case series'. Together they form a unique fingerprint.

  • Cite this