Recovery of the dog quadriceps after 10 weeks of immobilization followed by 4 weeks of remobilization

Richard L. Lieber*, Thalia McKee‐Woodburn, David H. Gershuni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Skeletal muscle fiber areas were measured in three heads of the dog quadriceps after 10 weeks of immobilization followed by 4 weeks of remobilization. Two‐way analysis of variance demonstrated a significant decrease in both type 1 (p < 0.005) and type 2 (p < 0.001) fiber area. However, there was no significant difference among the three heads of the quadriceps (p > 0.2). Although muscle fiber areas had not returned to control levels following remobilization, the area fraction of perimysial and epimysial connective tissue was not significantly different from control values (p > 0.15). These data suggest that although the degree of muscle atrophy following 10 weeks of immobilization is severe and muscle specific, following 4 weeks of remobilization, muscles uniformly recover to about 70% of control values.

Original languageEnglish (US)
Pages (from-to)408-412
Number of pages5
JournalJournal of Orthopaedic Research
Volume7
Issue number3
DOIs
StatePublished - May 1989

Keywords

  • Dog
  • Immobilization
  • Muscle fiber areas
  • Quadriceps
  • Remobilization

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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