Abstract
Graft-versus-host reaction (GVHR) enhanced the expression of endogenous xenotropic C-type RNA viruses and not of ecotropic C-type viruses in the spleens of CAF-1 hybrid mice. This observation suggests a specific xenotropic virus response during the GVHR in mice and indicates that ecotropic viruses are not necessarily expressed during GVHR. The possible role of xenotropic viruses in the GVHR-induced malignancy is considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 262-268 |
| Number of pages | 7 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1977 |
Funding
We thank Ms. Susan Gleazer, Mr. Bruce Howard, and Ms. Sylvia Johnson for expert technical assistance. This research was supported by USPHS Grants CA 10018, CA 13086, and AM 07937. J.A.L. is the recipient of Research Career Development Award CA 70990 from the National Cancer Institute. S.K.D. is a fellow in hematology supported by the Leukemia Society of America, Inc. REFERENCES 1. Schwartz, R. D., and Beldotti, L., Science 149, 1511, 1965. 2. Walford, R. L., Science 152, 78, 1966. 3. Hirsch, M. S., Black, P. H., Tracy, G. S., Leibowitz, S., and Schwartz, R. S., Proc. Nat. Acad. Sri. USA 67, 1914, 1970. 4. Carpenter, C. B.. Proc. Nat. Acad. Sci. USA 69, 1069, 1973. 5. Armstrong, M. Y. K., Black, F. L., and Richards, F. F., Nature New Biol. 325, 153, 1972. 6. Andre-Schwartz, J., Schwartz, R. S., Hirsch, M. S., Phillips, S. M., and Black, P. H., J. Nat. Cancer Inst. 51, 507, 1973. 7. Sherr, C. J., Lieber, M. M., and Todaro, G. J., Cell 1, 55, 1974. 8. Levy. J. A., Amer. J. Clin. Path. 62, 258, 1974. 9. Hartley, J. W., Rowe, W. P., and Huebner, R. J., J. Viral. 5, 221, 1970. 10. Lilly, F.. and Pincus, T.. Adv. Cancer Res. 17, 231, 1973. 11. Levy, J. A., Science 182, 1151, 1973. 12. Levy, J. A., and Pincus, T., Science 170, 326, 1970. 13. Aaronson, S. A., and Stephenson, J. R., Proc. Nat, Acad. Sri. USA 70, 2055, 1973. 14. Levy, J. A.. J. Rheumatoi. 2, 135, 1975. 15. Lieber. M. M., Sherr, C. J., and Todaro, G. J., Ilzt. J. Cancer 13, 587. 1974. 16. Due-Nguyen, H., Rosenblum, E. N., and Ziegler, R. F., J. Bacterial. 92, 1133, 1966. 17. Levy, J. A., J. Nat. Cancer Inst. 46, 1011, 1971. 18. Levy, M. A., Kazan, P.. Varnier, 0.. and Kleiman, H.. J. Viral. 16, 844, 1975. 19. Due-Nguyen, H., J. Viral. 2, 643, 1968. 20. Rowe, W. P., Pugh, W. E.. and Hartley, J. W., Virology 42, 1136, 1970. 21. Datta, S. K., Melief, C. J. M., and Schwartz, R. S., J. Nat. Cancer Inst. 55, 425. 1975. 22. Melief, C. J. M.. Datta, S. K., Louie. S., Johnson, S., Melief, M., and Schwartz, R. S., Proc. Sot. E.xp. Bioi. & Med. 149, 101.5, 1975. 23. Armstrong, M. Y. K., Gleichmann, E., Gleichmann, H., Beldotti. L., Andre-Schwartz, J., and Schwartz, R. S., J. Erp. Med. 132, 417, 1970. 24. Peters. R. L., Rabstein, L. S., Spahn, G. J., Madison, R. M., and Huebner, R. J., Inr. J. Cancer 10, 273, 1972.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology
