TY - JOUR
T1 - Recruitment of HIV and its receptors to dendritic cell-T cell junctions
AU - McDonald, David
AU - Wu, Li
AU - Bohks, Stacy M.
AU - KewalRamani, Vineet N.
AU - Unutmaz, Derya
AU - Hope, Thomas J.
PY - 2003/5/23
Y1 - 2003/5/23
N2 - Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigenspecific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.
AB - Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigenspecific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.
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U2 - 10.1126/science.1084238
DO - 10.1126/science.1084238
M3 - Article
C2 - 12730499
AN - SCOPUS:0038025223
SN - 0036-8075
VL - 300
SP - 1295
EP - 1297
JO - Science
JF - Science
IS - 5623
ER -
