Recruitment of HIV and its receptors to dendritic cell-T cell junctions

David McDonald, Li Wu, Stacy M. Bohks, Vineet N. KewalRamani, Derya Unutmaz, Thomas J. Hope*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

560 Scopus citations

Abstract

Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigenspecific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.

Original languageEnglish (US)
Pages (from-to)1295-1297
Number of pages3
JournalScience
Volume300
Issue number5623
DOIs
StatePublished - May 23 2003

ASJC Scopus subject areas

  • General

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