Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Kate M. Crossley*, Shruti Agnihotri, Joga Chaganti, Michael L. Rodriguez, Leon Patrick McNally, Nagagopal Venna, Sarah E. Turbett, Matthew Gutman, Adrienne Morey, Igor J. Koralnik, Bruce J. Brew

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalJournal of neurovirology
Volume22
Issue number4
DOIs
StatePublished - Aug 1 2016

Keywords

  • Neuroimmunology
  • Neurovirology
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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