Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Kate M. Crossley; Shruti Agnihotri; Joga Chaganti; Michael L. Rodriguez; Leon Patrick McNally; Nagagopal Venna; Sarah E. Turbett; Matthew Gutman; Adrienne Morey; Igor J. Koralnik; Bruce J. Brew

doi:10.1007/s13365-015-0419-y

Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Kate M. Crossley^*, Shruti Agnihotri, Joga Chaganti, Michael L. Rodriguez, Leon Patrick McNally, Nagagopal Venna, Sarah E. Turbett, Matthew Gutman, Adrienne Morey, Igor J. Koralnik, Bruce J. Brew

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

Original language	English (US)
Pages (from-to)	541-545
Number of pages	5
Journal	Journal of neurovirology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/s13365-015-0419-y
State	Published - Aug 1 2016

Keywords

Neuroimmunology
Neurovirology
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13365-015-0419-y

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Crossley, K. M., Agnihotri, S., Chaganti, J., Rodriguez, M. L., McNally, L. P., Venna, N., Turbett, S. E., Gutman, M., Morey, A., Koralnik, I. J., & Brew, B. J. (2016). Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals. Journal of neurovirology, 22(4), 541-545. https://doi.org/10.1007/s13365-015-0419-y

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abstract = "We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.",

keywords = "Neuroimmunology, Neurovirology, Progressive multifocal leukoencephalopathy",

author = "Crossley, {Kate M.} and Shruti Agnihotri and Joga Chaganti and Rodriguez, {Michael L.} and McNally, {Leon Patrick} and Nagagopal Venna and Turbett, {Sarah E.} and Matthew Gutman and Adrienne Morey and Koralnik, {Igor J.} and Brew, {Bruce J.}",

note = "Funding Information: Igor J. Koralnik was supported in part by NIH grants R01 047029 and R01 074995. The other authors all declare that they have no conflict of interest. Publisher Copyright: {\textcopyright} 2016, The Author(s).",

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doi = "10.1007/s13365-015-0419-y",

language = "English (US)",

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T1 - Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

AU - Crossley, Kate M.

AU - Agnihotri, Shruti

AU - Chaganti, Joga

AU - Rodriguez, Michael L.

AU - McNally, Leon Patrick

AU - Venna, Nagagopal

AU - Turbett, Sarah E.

AU - Gutman, Matthew

AU - Morey, Adrienne

AU - Koralnik, Igor J.

AU - Brew, Bruce J.

N1 - Funding Information: Igor J. Koralnik was supported in part by NIH grants R01 047029 and R01 074995. The other authors all declare that they have no conflict of interest. Publisher Copyright: © 2016, The Author(s).

PY - 2016/8/1

Y1 - 2016/8/1

N2 - We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

AB - We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

KW - Neuroimmunology

KW - Neurovirology

KW - Progressive multifocal leukoencephalopathy

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Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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