Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics

Rehan Karmali; Tahir S. Kafil; Aqieda Bayat; Bianca Honnekeri; Osamah Badwan; Felix Berglund; Paul Cremer; Allan L. Klein

doi:10.1016/j.jacadv.2024.101194

Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics

Rehan Karmali, Tahir S. Kafil, Aqieda Bayat, Bianca Honnekeri, Osamah Badwan, Felix Berglund, Paul Cremer, Allan L. Klein^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

Abstract

Recurrent pericarditis poses a significant challenge to patients and clinicians given its high morbidity and health care burden. Since the last iteration of European Society of Cardiology Guidelines in 2015, further insights have been gained into the pathophysiology, multimodality imaging assessment, and treatment of this condition. The purpose of this review is to discuss each of these aspects and highlight the role of imaging-guided therapy and interleukin-1 inhibitors in autoinflammatory phenotypes that together have transformed the care of these patients. Although future investigations are needed to optimize diagnostic surveillance and timing of therapy, recent evidence points at an encouraging paradigm shift in the treatment of recurrent pericarditis.

Original language	English (US)
Article number	101194
Journal	JACC: Advances
Volume	3
Issue number	9
DOIs	https://doi.org/10.1016/j.jacadv.2024.101194
State	Published - Sep 2024

Keywords

autoinflammatory phenotype
cardiac magnetic resonance
interleukin-1
multimodality imaging
recurrent pericarditis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Dentistry (miscellaneous)

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Cite this

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title = "Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics",

abstract = "Recurrent pericarditis poses a significant challenge to patients and clinicians given its high morbidity and health care burden. Since the last iteration of European Society of Cardiology Guidelines in 2015, further insights have been gained into the pathophysiology, multimodality imaging assessment, and treatment of this condition. The purpose of this review is to discuss each of these aspects and highlight the role of imaging-guided therapy and interleukin-1 inhibitors in autoinflammatory phenotypes that together have transformed the care of these patients. Although future investigations are needed to optimize diagnostic surveillance and timing of therapy, recent evidence points at an encouraging paradigm shift in the treatment of recurrent pericarditis.",

keywords = "autoinflammatory phenotype, cardiac magnetic resonance, interleukin-1, multimodality imaging, recurrent pericarditis",

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AU - Honnekeri, Bianca

AU - Badwan, Osamah

AU - Berglund, Felix

AU - Cremer, Paul

AU - Klein, Allan L.

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AB - Recurrent pericarditis poses a significant challenge to patients and clinicians given its high morbidity and health care burden. Since the last iteration of European Society of Cardiology Guidelines in 2015, further insights have been gained into the pathophysiology, multimodality imaging assessment, and treatment of this condition. The purpose of this review is to discuss each of these aspects and highlight the role of imaging-guided therapy and interleukin-1 inhibitors in autoinflammatory phenotypes that together have transformed the care of these patients. Although future investigations are needed to optimize diagnostic surveillance and timing of therapy, recent evidence points at an encouraging paradigm shift in the treatment of recurrent pericarditis.

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Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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