Red-Cell Clumping after Intravenous Contrast Medium (Cont.)

Syamal K. Datta, Avrum Z. Bluming

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: The letter by Poiesz attributing red-cell agglutinating activity to sodium diatrizoate (Hypaque)1 is not accurate. The technic of isolation of leukocytes from human blood as originally described by Böyum and mentioned by Mr. Poiesz does employ a Ficoll–Hypaque density-gradient system to aggregate red blood cells and accelerate separation from the mononuclear cells.2 The Ficoll and not the sodium diatrizoate, however, was reported by Böyum to be the red-cell aggregating agent. Ficoll, which is a sucrose polymer, shares this aggregating ability with other high polymer compounds, including dextran, hydroxyethylcellulose, methylcellulose, povidone (polyvinylpyrrolidone), fibrinogen, phytohemagglutinin and hexadimetrin bromide, all. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)1253
Number of pages1
JournalNew England Journal of Medicine
Issue number23
StatePublished - Dec 6 1973
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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