Redefining the serotonergic system by genetic lineage

Patricia Jensen, Anna F. Farago, Rajeshwar B. Awatramani, Michael M. Scott, Evan S. Deneris, Susan M. Dymecki

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Central serotonin-producing neurons are heterogeneous - differing in location, morphology, neurotoxin sensitivity and associated clinical disorders - but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.

Original languageEnglish (US)
Pages (from-to)417-419
Number of pages3
JournalNature neuroscience
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Neuroscience(all)

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