Reduced ΔFosB expression in the rat nucleus accumbens has causal role in the neuropathic pain phenotype

Sarah L. Pollema-Mays, Maria Virginia Centeno, Zheng Chang, Apkar Apkarian, Marco Martina*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The neuropathic pain phenotype is the consequence of functional and morphological reorganization of the PNS and CNS. This reorganization includes DRGs and the spinal cord, and extends to multiple supraspinal areas including the limbic and reward systems. Several recent papers show that acute manipulation of cortical and subcortical brain areas causally correlates with the cognitive, emotional and sensory components of neuropathic pain, yet mechanisms responsible for pain chronification remain largely unknown. Here we show that nucleus accumbens expression of ΔFos-B, a transcription factor that plays a critical role in addiction and in the brain response to stress, is reduced long term following peripheral neuropathic injury. Conversely, boosting ΔFos-B expression in the nucleus accumbens by viral transfection causes a significant and long-lasting improvement of the neuropathic allodynia. We suggest that ΔFos-B in the nucleus accumbens is a key modulator of long term gene expression leading to pain chronification.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalNeuroscience Letters
Volume702
DOIs
StatePublished - May 29 2019

Fingerprint

Nucleus Accumbens
Neuralgia
Phenotype
Pain
Limbic System
Diagnosis-Related Groups
Hyperalgesia
Brain
Reward
Transfection
Spinal Cord
Transcription Factors
Gene Expression
Wounds and Injuries

Keywords

  • Chronic pain
  • Gene expression
  • Immediate early genes
  • Limbic system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "The neuropathic pain phenotype is the consequence of functional and morphological reorganization of the PNS and CNS. This reorganization includes DRGs and the spinal cord, and extends to multiple supraspinal areas including the limbic and reward systems. Several recent papers show that acute manipulation of cortical and subcortical brain areas causally correlates with the cognitive, emotional and sensory components of neuropathic pain, yet mechanisms responsible for pain chronification remain largely unknown. Here we show that nucleus accumbens expression of ΔFos-B, a transcription factor that plays a critical role in addiction and in the brain response to stress, is reduced long term following peripheral neuropathic injury. Conversely, boosting ΔFos-B expression in the nucleus accumbens by viral transfection causes a significant and long-lasting improvement of the neuropathic allodynia. We suggest that ΔFos-B in the nucleus accumbens is a key modulator of long term gene expression leading to pain chronification.",
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Reduced ΔFosB expression in the rat nucleus accumbens has causal role in the neuropathic pain phenotype. / Pollema-Mays, Sarah L.; Centeno, Maria Virginia; Chang, Zheng; Apkarian, Apkar; Martina, Marco.

In: Neuroscience Letters, Vol. 702, 29.05.2019, p. 77-83.

Research output: Contribution to journalArticle

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AU - Chang, Zheng

AU - Apkarian, Apkar

AU - Martina, Marco

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