TY - JOUR
T1 - Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia
AU - Takayanagi, Mizuho
AU - Wentz, Jacqueline
AU - Takayanagi, Yoichiro
AU - Schretlen, David J.
AU - Ceyhan, Elvan
AU - Wang, Lei
AU - Suzuki, Michio
AU - Sawa, Akira
AU - Barta, Patrick E.
AU - Ratnanather, J. Tilak
AU - Cascella, Nicola G.
PY - 2013/11
Y1 - 2013/11
N2 - Background: Patients with deficit schizophrenia (D-SZ) differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects such as risk factors, neurobiological correlates, treatment response and clinical outcome. It has been debated if brain morphology could differentiate D-SZ from ND-SZ. Anterior cingulate gyrus (ACG) region regulates cognitive and emotional processing and past studies reported structural changes in this region in patients with SZ. Methods: 1.5-T 3D MRI scans were obtained from 18 D-SZ patients, 30 ND-SZ patients and 82 healthy controls (HCs). We used FreeSurfer-initalized labeled cortical distance mapping (FSLCDM) to measure ACG gray matter volume, cortical thickness, and area of the gray/white interface. Furthermore, cortical thickness was compared among the 3 groups using the pooled labeled cortical distance mapping (LCDM) method. Results: The ACG cortex of the D-SZ group was thinner than the ND-SZ group. Pooled LCDM demonstrated that the ACG cortex was bilaterally thinner in both the ND-SZ group and the D-SZ group compared with the control group. The right ACG gray matter volume was significantly reduced in D-SZ patients as compared with healthy controls (p= 0.005. Conclusion: Our data suggest that qualitative, categorical differences in neuroanatomy may distinguish between deficit and non-deficit subtypes of schizophrenia.
AB - Background: Patients with deficit schizophrenia (D-SZ) differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects such as risk factors, neurobiological correlates, treatment response and clinical outcome. It has been debated if brain morphology could differentiate D-SZ from ND-SZ. Anterior cingulate gyrus (ACG) region regulates cognitive and emotional processing and past studies reported structural changes in this region in patients with SZ. Methods: 1.5-T 3D MRI scans were obtained from 18 D-SZ patients, 30 ND-SZ patients and 82 healthy controls (HCs). We used FreeSurfer-initalized labeled cortical distance mapping (FSLCDM) to measure ACG gray matter volume, cortical thickness, and area of the gray/white interface. Furthermore, cortical thickness was compared among the 3 groups using the pooled labeled cortical distance mapping (LCDM) method. Results: The ACG cortex of the D-SZ group was thinner than the ND-SZ group. Pooled LCDM demonstrated that the ACG cortex was bilaterally thinner in both the ND-SZ group and the D-SZ group compared with the control group. The right ACG gray matter volume was significantly reduced in D-SZ patients as compared with healthy controls (p= 0.005. Conclusion: Our data suggest that qualitative, categorical differences in neuroanatomy may distinguish between deficit and non-deficit subtypes of schizophrenia.
KW - Anterior cingulate cortex
KW - Cortical thickness
KW - Deficit schizophrenia
KW - Schizophrenia
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U2 - 10.1016/j.schres.2013.07.036
DO - 10.1016/j.schres.2013.07.036
M3 - Article
C2 - 24035178
AN - SCOPUS:84886300046
SN - 0920-9964
VL - 150
SP - 484
EP - 490
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -
