Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan*, Scott L. Rauch, Hans C. Breiter, Igor D. Grachev, Lee Baer, David N. Kennedy, Nancy J. Keuthen, Cary R. Savage, Peter A. Manzo, Verne S. Caviness, Michael A. Jenike

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalBiological psychiatry
Volume42
Issue number1
DOIs
StatePublished - Jul 1 1997

Keywords

  • Basal ganglia
  • Morphometric magnetic resonance imaging
  • Trichotillomania
  • putamen

ASJC Scopus subject areas

  • Biological Psychiatry

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