Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan; Scott L. Rauch; Hans C. Breiter; Igor D. Grachev; Lee Baer; David N. Kennedy; Nancy J. Keuthen; Cary R. Savage; Peter A. Manzo; Verne S. Caviness; Michael A. Jenike

doi:10.1016/S0006-3223(96)00297-1

Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan^*, Scott L. Rauch, Hans C. Breiter, Igor D. Grachev, Lee Baer, David N. Kennedy, Nancy J. Keuthen, Cary R. Savage, Peter A. Manzo, Verne S. Caviness, Michael A. Jenike

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Biological psychiatry
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0006-3223(96)00297-1
State	Published - Jul 1 1997

Keywords

Basal ganglia
Morphometric magnetic resonance imaging
Trichotillomania
putamen

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/S0006-3223(96)00297-1

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@article{bf600deab205404980cc2a87fe402833,

title = "Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging",

abstract = "A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.",

keywords = "Basal ganglia, Morphometric magnetic resonance imaging, Trichotillomania, putamen",

author = "O'Sullivan, {Richard L.} and Rauch, {Scott L.} and Breiter, {Hans C.} and Grachev, {Igor D.} and Lee Baer and Kennedy, {David N.} and Keuthen, {Nancy J.} and Savage, {Cary R.} and Manzo, {Peter A.} and Caviness, {Verne S.} and Jenike, {Michael A.}",

year = "1997",

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doi = "10.1016/S0006-3223(96)00297-1",

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AU - O'Sullivan, Richard L.

AU - Rauch, Scott L.

AU - Breiter, Hans C.

AU - Grachev, Igor D.

AU - Baer, Lee

AU - Kennedy, David N.

AU - Keuthen, Nancy J.

AU - Savage, Cary R.

AU - Manzo, Peter A.

AU - Caviness, Verne S.

AU - Jenike, Michael A.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

AB - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

KW - Basal ganglia

KW - Morphometric magnetic resonance imaging

KW - Trichotillomania

KW - putamen

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JO - Biological psychiatry

JF - Biological psychiatry

IS - 1

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Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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