Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Nicolas Rüsch; Tobias Bracht; Björn W. Kreher; Susanne Schnell; Volkmar Glauche; Kamil A. Il'yasov; Dieter Ebert; Klaus Lieb; Jürgen Hennig; Dorothee Saur; Ludger Tebartz van Elst

doi:10.1016/j.pscychresns.2009.08.004

Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Nicolas Rüsch^*, Tobias Bracht, Björn W. Kreher, Susanne Schnell, Volkmar Glauche, Kamil A. Il'yasov, Dieter Ebert, Klaus Lieb, Jürgen Hennig, Dorothee Saur, Ludger Tebartz van Elst

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.

Original language	English (US)
Pages (from-to)	151-154
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	181
Issue number	2
DOIs	https://doi.org/10.1016/j.pscychresns.2009.08.004
State	Published - Feb 28 2010

Funding

We are grateful to all subjects who participated in this study. Nicolas Rüsch was supported by a Marie Curie Outgoing International Fellowship of the European Union . This work was also supported by a grant from the Ministry of Science, Research and the Arts of Baden-Württemberg AZ : 23-7532.22-11/1 and the Federal Ministry for Education and Research BMBF 01GV0606 to Dr. Ludger Tebartz van Elst. All authors report no biomedical financial interests or potential conflicts of interest.

Keywords

Diffusion-tensor imaging
Fiber tracking
Structural neuroimaging

ASJC Scopus subject areas

Psychiatry and Mental health
Radiology Nuclear Medicine and imaging
Neuroscience (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2009.08.004

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Rüsch, N., Bracht, T., Kreher, B. W., Schnell, S., Glauche, V., Il'yasov, K. A., Ebert, D., Lieb, K., Hennig, J., Saur, D., & van Elst, L. T. (2010). Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder. Psychiatry Research - Neuroimaging, 181(2), 151-154. https://doi.org/10.1016/j.pscychresns.2009.08.004

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abstract = "Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.",

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note = "Funding Information: We are grateful to all subjects who participated in this study. Nicolas R{\"u}sch was supported by a Marie Curie Outgoing International Fellowship of the European Union . This work was also supported by a grant from the Ministry of Science, Research and the Arts of Baden-W{\"u}rttemberg AZ : 23-7532.22-11/1 and the Federal Ministry for Education and Research BMBF 01GV0606 to Dr. Ludger Tebartz van Elst. All authors report no biomedical financial interests or potential conflicts of interest. ",

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N2 - Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.

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Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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