Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Nicolas Rüsch*, Tobias Bracht, Björn W. Kreher, Susanne Schnell, Volkmar Glauche, Kamil A. Il'yasov, Dieter Ebert, Klaus Lieb, Jürgen Hennig, Dorothee Saur, Ludger Tebartz van Elst

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume181
Issue number2
DOIs
StatePublished - Feb 28 2010

Keywords

  • Diffusion-tensor imaging
  • Fiber tracking
  • Structural neuroimaging

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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