Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice

M. Zhang*, Y. Shi, D. Magit, P. A. Furth, R. Sager

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Maspin is a unique serpin involved in the suppression of tumor growth and metastasis. To investigate whether increased levels of maspin protect against tumor progression in vivo, we established a transgenic model in which maspin is targeted to mammary epithelial cells by the Whey Acidic Protein (WAP) promoter for overexpression. We crossed these WAP-maspin transgenic mice with the WAP-TAg mouse model of tumor progression. Maspin overexpression increased the rate of apoptosis of both preneoplastic and carcinomatous mammary epithelial cells. Maspin reduced tumor growth through a combination of reduced angiogenesis and increased apoptosis. The number of pulmonary metastases was reduced in the presence of maspin overexpression. These data demonstrate that targeted overexpression of maspin can inhibit tumor progression in vivo, likely through a combination of increased apoptosis, decreased angiogenesis, and inhibition of tumor cell migration.

Original languageEnglish (US)
Pages (from-to)6053-6058
Number of pages6
JournalOncogene
Volume19
Issue number52
DOIs
StatePublished - Dec 7 2000

Keywords

  • Mammary tumor progression
  • Maspin
  • WAP-TAg transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice'. Together they form a unique fingerprint.

Cite this