TY - JOUR
T1 - Reduction of fertility in female baboons immunized with lactate dehydrogenase C4
AU - Goldberg, E.
AU - Wheat, T. E.
AU - Powell, J. E.
AU - Stevens, V. C.
N1 - Funding Information:
Received July 8, 1980; revised and accepted October 7,1980. *Supported in part by National Institutes of Health Grant HD05863 and by Contract H9/1811134 from the World Health Organization. tReprint requests: Erwin Goldberg, Ph.D., Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201. :j:Department of Biological Sciences, Northwestern University. §Department of Obstetrics and Gynecology, Ohio State University.
PY - 1981
Y1 - 1981
N2 - Immunization of female rabbits and mice with the sperm-specific isozyme of lactate dehydrogenase, LDH-C4, significantly reduced their fertility. Similar studies have been extended to nonhuman primates. Two female baboons, immunized with human LDH-C4, produced low antibody titers. These titers were markedly enhanced by booster injections of murine LDH-C4. An additional seven female baboons responded with relatively high antibody titers after receiving murine LDH-C4 as both priming and booster dosages. All nine females received injections of murine LDH-C4 at varying times determined by serum titer levels during fertility studies. These antisera reacted with human, mouse, and baboon LDH-C4. In a series of breeding experiments, 22 of 30 matings, or 73%, were infertile as compared with 28% in control matings. This contraceptive effect of the vaccine containing LDH-C4 was related to antibody titer and was reversible. Normal pregnancies ensued in animals in which the titer declined after termination of booster injections of vaccine.
AB - Immunization of female rabbits and mice with the sperm-specific isozyme of lactate dehydrogenase, LDH-C4, significantly reduced their fertility. Similar studies have been extended to nonhuman primates. Two female baboons, immunized with human LDH-C4, produced low antibody titers. These titers were markedly enhanced by booster injections of murine LDH-C4. An additional seven female baboons responded with relatively high antibody titers after receiving murine LDH-C4 as both priming and booster dosages. All nine females received injections of murine LDH-C4 at varying times determined by serum titer levels during fertility studies. These antisera reacted with human, mouse, and baboon LDH-C4. In a series of breeding experiments, 22 of 30 matings, or 73%, were infertile as compared with 28% in control matings. This contraceptive effect of the vaccine containing LDH-C4 was related to antibody titer and was reversible. Normal pregnancies ensued in animals in which the titer declined after termination of booster injections of vaccine.
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U2 - 10.1016/s0015-0282(16)45325-2
DO - 10.1016/s0015-0282(16)45325-2
M3 - Article
C2 - 7202745
AN - SCOPUS:0019504117
SN - 0015-0282
VL - 35
SP - 214
EP - 217
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -
