TY - JOUR
T1 - Reduction of image artifacts in mice by bladder flushing with a novel double-lumen urethral catheter.
AU - Haney, Chad R.
AU - Parasca, Adrian D.
AU - Ichikawa, Kazuhiro
AU - Williams, Benjamin B.
AU - Elas, Martyna
AU - Pelizzari, Charles A.
AU - Halpern, Howard J.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2006/7
Y1 - 2006/7
N2 - In electron paramagnetic resonance imaging (EPRI), the accumulation of contrast agent in the bladder can create a very large source of signal, often far greater than that of the organ of interest. Mouse model images have become increasingly important in preclinical testing. To minimize bladder accumulation on mouse images, we developed a novel, minimally invasive, MRI/EPRI-friendly procedure for flushing a female mouse bladder. It is also applicable to other imaging techniques, for example, PET, SPECT, etc., where contrast agent accumulation in the bladder is also undesirable. A double-lumen urethral catheter was developed, using a standard IV catheter with a silicone tube extension, having a polyethylene tube threaded into the IV catheter. Flushing of the bladder provides a substantial reduction in artifacts, as shown in images of tumors in mice.
AB - In electron paramagnetic resonance imaging (EPRI), the accumulation of contrast agent in the bladder can create a very large source of signal, often far greater than that of the organ of interest. Mouse model images have become increasingly important in preclinical testing. To minimize bladder accumulation on mouse images, we developed a novel, minimally invasive, MRI/EPRI-friendly procedure for flushing a female mouse bladder. It is also applicable to other imaging techniques, for example, PET, SPECT, etc., where contrast agent accumulation in the bladder is also undesirable. A double-lumen urethral catheter was developed, using a standard IV catheter with a silicone tube extension, having a polyethylene tube threaded into the IV catheter. Flushing of the bladder provides a substantial reduction in artifacts, as shown in images of tumors in mice.
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M3 - Article
C2 - 16954032
AN - SCOPUS:39049194769
SN - 1535-3508
VL - 5
SP - 175
EP - 179
JO - Molecular imaging : official journal of the Society for Molecular Imaging
JF - Molecular imaging : official journal of the Society for Molecular Imaging
IS - 3
ER -