TY - JOUR
T1 - Reference interval determination for anabasine
T2 - A biomarker of active tobacco use
AU - Suh-Lailam, Brenda B.
AU - Haglock-Adler, Carrie J.
AU - Carlisle, Heidi J.
AU - Ohman, Trent
AU - McMillin, Gwendolyn A.
N1 - Funding Information:
Funding to support this study was provided by ARUP Laboratories and the ARUP Institute for Clinical and Experimental Pathology.
PY - 2014/9
Y1 - 2014/9
N2 - Laboratory detection of nicotine exposure is important for establishing eligibility for organ transplant and elective surgery. Nicotine testing is also used to verify compliance with nicotine replacement therapies (NRT), smoking cessation programs and for life insurance purposes. Nicotine metabolites, such as cotinine and trans-30-hydroxycotinine, are used as biomarkers of nicotine exposure. For some clinical applications, it is important to distinguish between active use of tobacco products versus NRT. Anabasine is a tobacco alkaloid that has been used as a biomarker of active tobacco use. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure. Here, we determine the reference interval for anabasine in the urine of nonsmokers and compare it to the range of anabasine concentrations observed in the presence or absence of nicotine metabolites.
AB - Laboratory detection of nicotine exposure is important for establishing eligibility for organ transplant and elective surgery. Nicotine testing is also used to verify compliance with nicotine replacement therapies (NRT), smoking cessation programs and for life insurance purposes. Nicotine metabolites, such as cotinine and trans-30-hydroxycotinine, are used as biomarkers of nicotine exposure. For some clinical applications, it is important to distinguish between active use of tobacco products versus NRT. Anabasine is a tobacco alkaloid that has been used as a biomarker of active tobacco use. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure. Here, we determine the reference interval for anabasine in the urine of nonsmokers and compare it to the range of anabasine concentrations observed in the presence or absence of nicotine metabolites.
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U2 - 10.1093/jat/bku059
DO - 10.1093/jat/bku059
M3 - Article
C2 - 24939383
AN - SCOPUS:84907348394
SN - 0146-4760
VL - 38
SP - 416
EP - 420
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
IS - 7
M1 - bku059
ER -
