Refocusing on the Primary Prevention of Heart Failure

Lua A. Jafari, Rachel M. Suen, Sadiya S. Khan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of review: The burden of heart failure (HF) is a significant national and global public health problem, with prevalence rates on the rise. Given the significant morbidity, mortality, and healthcare costs attributable to HF, it is of utmost importance to utilize preventive strategies to prevent the development of HF. Therefore, we sought to address how a multi-modal risk assessment approach can be used to stratify patients for HF risk and guide implementation of therapeutic strategies to prevent HF. Recent findings: New externally validated, multivariate prediction models for incident HF can be applied in the general population and may be used to aide clinicians in assessing individualized HF risk and screening for HF. Recent clinical trial data suggest a natriuretic peptide biomarker-based screening approach coupled with team-based cardiovascular care to focus on optimization of guideline-directed medical therapy may help prevent new-onset HF. However, widespread implementation of clinical risk scores and/or biomarkers is needed. Summary: In addition to promoting a heart healthy lifestyle, prevention and management of modifiable risk factors, including intensive blood pressure lowering and use of sodium-glucose cotransporter-2 inhibitors, can prevent incident HF.

Original languageEnglish (US)
Article number13
JournalCurrent Treatment Options in Cardiovascular Medicine
Issue number7
StatePublished - Jul 1 2020


  • Diabetes
  • Heart failure
  • Hypertension
  • Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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