Refractory vasospasm with a malignant course

Ananth Kumar, Harish Chandna, Vimala Santhanam, Pablo Denes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We present a patient with two rare disorders, recurrent vasospastic angina leading to cardiac transplant and acute aortic occlusion. The patient had recurrent episodes of coronary vasospasm presenting with unstable angina, acute myocardial infarction, and sudden cardiac death in spite of adequate therapy with nitrates and calcium-channel blockers. He went on to have a cardiac transplant. The patient later presented with acute aortic occlusion with concomitant renal and mesenteric artery spasm. The circumstances of the presentation raise the possibility of a generalized vasospastic predisposition that is responsible for both events. Smoking, the only known major risk factor other than atherosclerosis, was noted to be temporally related to both events in our patient.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalClinical Cardiology
Issue number2
StatePublished - 2000


  • Aortic occlusion
  • Cardiac transplantation
  • Smoking
  • Vasospastic angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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