Regeneration of the Guinea Pig Parotid Gland after 4-hydroxyaminoquinoline-1-oxide-lnduced Necrosis (39503)

M. S. Rao*, J. K. Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

A single iv injection of 4-hy-droxyaminoquinoline-1-oxide (4-HAQO) in a dose of 22 mg/kg body weight induced marked necrosis of parotid acinar tissue in guinea pigs within 48 hr. After the necrotic phase, marked regenerative activity of the acinar cells was noted. [3H]Thymidine auto-radiographic studies revealed a labeling index of 15% cells in the parotid gland at 72 hr after 4-HAQO injection. A significant increase in the mitotic activity of the parotid acinar cells was also evident at 72 and 78 hr after 4-HAQO administration. The acinar cell repair, as well as formation of the new acini, were complete at 108 hr. It is clear from the studies that 4-HAQO, a pancreati-cotoxic agent and a potent carcinogen, also causes necrosis of the parotid acinar tissue, which is followed by regeneration and restitution.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume153
Issue number1
DOIs
StatePublished - Oct 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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