Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats

Jaak Panksepp; Jeff Burgdorf; Margery C. Beinfeld; Roger A. Kroes; Joseph R. Moskal

doi:10.1016/j.brainres.2004.07.076

Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats

Jaak Panksepp, Jeff Burgdorf, Margery C. Beinfeld, Roger A. Kroes, Joseph R. Moskal

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and has been implicated in the regulation of a diversity of emotions and motivations including negative affect and stress responses. In this experiment, we assayed levels of CCK (CCK4/5 and CCK8) from tissue homogenates in intruder animals 6 h after resident-intruder inter-male aggression. Intruder animals that demonstrated submissive behavior (freezing and 22-kHz ultrasonic vocalizations) had higher levels of CCK in the tegmentum and posterior cortex as compared to non-submissive (i.e., "Friendly") intruder animals. Ultrasonic vocalizations (22-kHz) were positively correlated with CCK levels in the tegmentum, posterior cortex and pituitary. These data suggest that CCK may play a role in the generation of negative affective states indexed by 22-kHz ultrasonic calls in certain regions of the brain.

Original language	English (US)
Pages (from-to)	75-84
Number of pages	10
Journal	Brain research
Volume	1025
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.07.076
State	Published - Oct 29 2004

Funding

This work was supported by a grant from the Falk Foundation and NIMH grant 1R21MH066731-01.

Keywords

Aggression
Cholecystokinin
Dominance
Neurochemistry
Rat
Social emotion
Social loss
Ultrasonic vocalization

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/j.brainres.2004.07.076

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title = "Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats",

abstract = "Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and has been implicated in the regulation of a diversity of emotions and motivations including negative affect and stress responses. In this experiment, we assayed levels of CCK (CCK4/5 and CCK8) from tissue homogenates in intruder animals 6 h after resident-intruder inter-male aggression. Intruder animals that demonstrated submissive behavior (freezing and 22-kHz ultrasonic vocalizations) had higher levels of CCK in the tegmentum and posterior cortex as compared to non-submissive (i.e., {"}Friendly{"}) intruder animals. Ultrasonic vocalizations (22-kHz) were positively correlated with CCK levels in the tegmentum, posterior cortex and pituitary. These data suggest that CCK may play a role in the generation of negative affective states indexed by 22-kHz ultrasonic calls in certain regions of the brain.",

keywords = "Aggression, Cholecystokinin, Dominance, Neurochemistry, Rat, Social emotion, Social loss, Ultrasonic vocalization",

author = "Jaak Panksepp and Jeff Burgdorf and Beinfeld, {Margery C.} and Kroes, {Roger A.} and Moskal, {Joseph R.}",

note = "Funding Information: This work was supported by a grant from the Falk Foundation and NIMH grant 1R21MH066731-01.",

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AU - Beinfeld, Margery C.

AU - Kroes, Roger A.

AU - Moskal, Joseph R.

N1 - Funding Information: This work was supported by a grant from the Falk Foundation and NIMH grant 1R21MH066731-01.

PY - 2004/10/29

Y1 - 2004/10/29

N2 - Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and has been implicated in the regulation of a diversity of emotions and motivations including negative affect and stress responses. In this experiment, we assayed levels of CCK (CCK4/5 and CCK8) from tissue homogenates in intruder animals 6 h after resident-intruder inter-male aggression. Intruder animals that demonstrated submissive behavior (freezing and 22-kHz ultrasonic vocalizations) had higher levels of CCK in the tegmentum and posterior cortex as compared to non-submissive (i.e., "Friendly") intruder animals. Ultrasonic vocalizations (22-kHz) were positively correlated with CCK levels in the tegmentum, posterior cortex and pituitary. These data suggest that CCK may play a role in the generation of negative affective states indexed by 22-kHz ultrasonic calls in certain regions of the brain.

AB - Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and has been implicated in the regulation of a diversity of emotions and motivations including negative affect and stress responses. In this experiment, we assayed levels of CCK (CCK4/5 and CCK8) from tissue homogenates in intruder animals 6 h after resident-intruder inter-male aggression. Intruder animals that demonstrated submissive behavior (freezing and 22-kHz ultrasonic vocalizations) had higher levels of CCK in the tegmentum and posterior cortex as compared to non-submissive (i.e., "Friendly") intruder animals. Ultrasonic vocalizations (22-kHz) were positively correlated with CCK levels in the tegmentum, posterior cortex and pituitary. These data suggest that CCK may play a role in the generation of negative affective states indexed by 22-kHz ultrasonic calls in certain regions of the brain.

KW - Aggression

KW - Cholecystokinin

KW - Dominance

KW - Neurochemistry

KW - Rat

KW - Social emotion

KW - Social loss

KW - Ultrasonic vocalization

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Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats

Abstract

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Keywords

ASJC Scopus subject areas

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