Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

Sarah J. Catchlove; Todd B. Parrish; Yufen Chen; Helen Macpherson; Matthew E. Hughes; Andrew Pipingas

doi:10.1177/1179069518785151

Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

Sarah J. Catchlove^*, Todd B. Parrish, Yufen Chen, Helen Macpherson, Matthew E. Hughes, Andrew Pipingas

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO ₂ inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.

Original language	English (US)
Journal	Journal of Experimental Neuroscience
Volume	12
DOIs	https://doi.org/10.1177/1179069518785151
State	Published - Jul 5 2018

Keywords

Cerebrovascular reactivity
cognition
healthy aging
magnetic resonance imaging (MRI)
memory

ASJC Scopus subject areas

Neuroscience(all)

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10.1177/1179069518785151

Cite this

@article{e2d0a230eeae4c5e8bd2aad8777b3a80,

title = "Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging",

abstract = " Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO 2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB{\textregistered} and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.",

keywords = "Cerebrovascular reactivity, cognition, healthy aging, magnetic resonance imaging (MRI), memory",

author = "Catchlove, {Sarah J.} and Parrish, {Todd B.} and Yufen Chen and Helen Macpherson and Hughes, {Matthew E.} and Andrew Pipingas",

note = "Funding Information: Research was supported by a grant from the Barbara Dicker Brain Sciences Association. ME Hughes is supported by the Australian National Imaging Facility. Funding Information: FundIng: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by a grant from the Barbara Dicker Brain Sciences Foundation. Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2018",

month = jul,

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doi = "10.1177/1179069518785151",

language = "English (US)",

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T1 - Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

AU - Catchlove, Sarah J.

AU - Parrish, Todd B.

AU - Chen, Yufen

AU - Macpherson, Helen

AU - Hughes, Matthew E.

AU - Pipingas, Andrew

N1 - Funding Information: Research was supported by a grant from the Barbara Dicker Brain Sciences Association. ME Hughes is supported by the Australian National Imaging Facility. Funding Information: FundIng: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by a grant from the Barbara Dicker Brain Sciences Foundation. Publisher Copyright: © The Author(s) 2018.

PY - 2018/7/5

Y1 - 2018/7/5

N2 - Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO 2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.

AB - Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO 2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.

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ER -

Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

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