Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

Sarah J. Catchlove*, Todd B. Parrish, Yufen Chen, Helen Macpherson, Matthew E. Hughes, Andrew Pipingas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO 2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.

Original languageEnglish (US)
JournalJournal of Experimental Neuroscience
StatePublished - Jul 5 2018


  • Cerebrovascular reactivity
  • cognition
  • healthy aging
  • magnetic resonance imaging (MRI)
  • memory

ASJC Scopus subject areas

  • Neuroscience(all)


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