Regional variation in cerebral perfusion during acute hypertension

Allan M. Burke*, Joel H. Greenberg, John Sladky, Martin Reivich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Regional cerebral blood flow (rCBF) was measured in rats to define the autoregulatory response at different levels of hypertension. Mean arterial blood pressure (MABP) was raised with IV metaraminol. rCBF was measured using14C-iodoantipyrine. Autoregulation was intact in normotensive animals and those with MABP of 152 to 158 mm Hg. At higher pressures, autoregulation was abnormal and heterogeneous. Hyperperfusion was most prominent in cerebellum, parietal gray matter, thalamus, striatum, and pons. These anatomic sites are recognized sites of hypertensive hemorrhage in humans.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
Issue number1
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Clinical Neurology


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