Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation

Shin Yoo, Markus Rottmann, Jason Ng, David Johnson, Bassel Shanab, Anna Pfenniger, Gail Elizabeth Geist, Suman Mandava, Amy Burrell, Wenwei Zhang, J. Andrew Wasserstrom, Bradley P. Knight, Rod Passman, Jeffrey J. Goldberger, Rishi Arora*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient treatment for persistent AF. Using biatrial high-density electrophysiologic mapping in a canine rapid atrial pacing model of AF, we systematically investigated the relationship of electrogram morphology recurrence (EMR) (Rec% and CLR) with established AF electrogram parameters and tissue characteristics. Rec% correlates with stability of rotational activity and with the spatial distribution of parasympathetic nerve fibers. These results have indicated that EMR may therefore be a viable therapeutic target in persistent AF.

Original languageEnglish (US)
Pages (from-to)68-84
Number of pages17
JournalJACC: Basic to Translational Science
Volume8
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • arrhythmias
  • atrial fibrillation
  • fibrosis
  • mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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