Regression of hypertrophic cardiomyopathy after modified konno procedure

Jose A. Quinones*, Serafin Y. DeLeon, Dolores A. Vitullo, Joanne Hofstra, David J. Cziperle, Kalavathi P. Shenoy, Timothy J. Bell, Elizabeth A. Fisher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background.: Septal myotomy-myectomy has been known to decrease the incidence of sudden death and produce regression in hypertrophic obstructive cardiomyopathy. Use of β-blockers or calcium-channel blockers generally does not cause regression of the disease. Methods.: Having successfully performed modified Konno procedures in 13 patients with effective relief of diffuse subaortic stenosis, we applied the procedure in 2 patients with hypertrophic obstructive cardiomyopathy. Both patients (18 and 12 years old, respectively) presented with syncope, angina at rest, and dyspnea despite being on calcium channel blocker therapy. The echocardiographic outflow gradients were 66 mm Hg and 88 mm Hg, respectively, with moderate mitral regurgitation. Results.: Both patients had uneventful postoperative course. At 2 years and 1.5 years postoperatively, both patients were free of angina and syncopal episodes. Echocardiography showed absence of outflow gradients and mitral regurgitation. In 1 patient the septal and posterior wall thickness decreased from 3.4 and 1.7 cm preoperatively to 2.6 and 0.9 cm, respectively, postoperatively. In the other patient, the thickness decreased from 2.4 and 0.9 cm preoperatively to 0.8 and 0.7 cm, respectively, postoperatively. Left atrial diameter decreased from 5.4 to 4.7 cm in 1 patient, 3.5 to 2.6 cm in the other. Conclusions.: We believe that the modified Konno procedure could produce more effective relief of obstruction and, therefore, significant regression and further reduction in sudden death in hypertrophic obstructive cardiomyopathy. On the basis of our experience, albeit limited, we encourage its application.

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
JournalThe Annals of thoracic surgery
Issue number5
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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