Regression of rat primary mammary tumors following dietary d-limonene

J. A. Elegbede, C. E. Elson, M. A. Tanner, A. Qureshi, M. N. Gould

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The effects of d-limonene on rat mammary tumors were investigated. Following the appearance of mammary tumors induced by 7,12-dimethylbenz[a]anthracene in female (W/Fu x F344)F2 rats, animals were assigned to pairs in which 1 rat was fed a diet containing 10% d-limonene and the other was pair fed an isocaloric diet containing 10% cellulose. There was a highly significant increase in the regression of the first tumors in the rats fed d-limonene. In addition, d-limonene given at this time inhibited the formation of subsequent multiple tumors in these rats.

Original languageEnglish (US)
Pages (from-to)323-325
Number of pages3
JournalJournal of the National Cancer Institute
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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