Regulation and cloning of microbial chitinase genes

P. A. Felse, T. Panda*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

84 Scopus citations

Abstract

A range of chitinase genes from microorganisms have been cloned and the potential uses of these genetically manipulated organisms are being investigated by various researchers. Fungi and yeast are better producers of chitinase than bacteria. Since fungi grow at a slower rate, there have been efforts to clone the fungal chitinase genes into fast-growing bacteria. This review gives a brief survey of recent progress in the regulation and cloning of microbial chitinase genes. Emphasis is placed on the post-translational modification and localization of the recombinant protein in the host. Various amino acid domains are present in this protein. The mode of catalytic activity of the recombinant protein in comparison to the wild-type protein is discussed in the available literature. The different mechanisms involved in the regulation of chitinase genes from various microorganisms is discussed by the researchers. The scope of future research and conclusions yet to be obtained in this particular area are also outlined in this review.

Original languageEnglish (US)
Pages (from-to)141-151
Number of pages11
JournalApplied Microbiology and Biotechnology
Volume51
Issue number2
DOIs
StatePublished - Mar 13 1999

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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