Regulation and epigenetic control of transcription at the nuclear periphery

Sara Ahmed*, Jason H. Brickner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

The localization of DNA within the nucleus influences the regulation of gene transcription. Subnuclear environments at the nuclear periphery promote gene silencing and activation. Silenced regions of the genome, such as centromeres and telomeres, are statically tethered to the nuclear envelope. Recent work in yeast has revealed that certain genes can undergo dynamic recruitment to the periphery upon transcriptional activation. For such genes, localization to the periphery has been suggested to improve mRNA export and favor optimal transcription. In addition, maintenance of peripheral localization confers cellular memory of previous transcriptional activation, enabling cells to adapt rapidly to transcriptional cues.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalTrends in Genetics
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Genetics

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