Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

Yvette C. Wong, Soojin Kim, Wesley Peng, Dimitri Krainc*

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Mitochondrial and lysosomal function are intricately related and critical for maintaining cellular homeostasis, as highlighted by multiple diseases linked to dysfunction of both organelles. Recent work using high-resolution microscopy demonstrates the dynamic formation of inter-organelle membrane contact sites between mitochondria and lysosomes, allowing for their direct interaction in a pathway distinct from mitophagy or lysosomal degradation of mitochondrial-derived vesicles. Mitochondria–lysosome contact site tethering is mechanistically regulated by mitochondrial proteins promoting Rab7 GTP hydrolysis, and allows for the bidirectional crosstalk between mitochondria and lysosomes and the regulation of their organelle network dynamics, including mitochondrial fission. In this review, we summarize recent advances in mitochondria–lysosome contact site regulation and function, and discuss their potential roles in cellular homeostasis and various human diseases.

Original languageEnglish (US)
Pages (from-to)500-513
Number of pages14
JournalTrends in Cell Biology
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 1 2019

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Keywords

  • Rab7 GTP hydrolysis
  • disease
  • inter-organelle membrane contact site
  • lysosome
  • mitochondria
  • mitochondrial fission
  • organelle dynamics

ASJC Scopus subject areas

  • Cell Biology

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