Regulation and functions of integrin α2 in cell adhesion and disease

Valery Adorno-Cruz; Huiping Liu

doi:10.1016/j.gendis.2018.12.003

Regulation and functions of integrin α2 in cell adhesion and disease

Valery Adorno-Cruz, Huiping Liu^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta (β) subunit with affinity for different extracellular membrane components. The integrin family includes 24 known members that actively regulate cellular growth, differentiation, and apoptosis. Each integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the family. As many reviews have covered the general integrin family in molecular and cellular studies in life science, this review will focus on the specific regulation, function, and signaling of integrin α2 subunit (CD49b, VLA-2; encoded by the gene ITGA2) in partnership with β1 (CD29) subunit in normal and cancer cells. Its roles in cell adhesion, cell motility, angiogenesis, stemness, and immune/blood cell regulations are discussed. The pivotal role of integrin α2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target.

Original language	English (US)
Pages (from-to)	16-24
Number of pages	9
Journal	Genes and Diseases
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.gendis.2018.12.003
State	Published - Mar 2019

Keywords

CD49b
Integrin α2
Molecular mechanisms
Regulation
Signaling

ASJC Scopus subject areas

Genetics(clinical)
Molecular Biology
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.gendis.2018.12.003

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title = "Regulation and functions of integrin α2 in cell adhesion and disease",

abstract = "Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta (β) subunit with affinity for different extracellular membrane components. The integrin family includes 24 known members that actively regulate cellular growth, differentiation, and apoptosis. Each integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the family. As many reviews have covered the general integrin family in molecular and cellular studies in life science, this review will focus on the specific regulation, function, and signaling of integrin α2 subunit (CD49b, VLA-2; encoded by the gene ITGA2) in partnership with β1 (CD29) subunit in normal and cancer cells. Its roles in cell adhesion, cell motility, angiogenesis, stemness, and immune/blood cell regulations are discussed. The pivotal role of integrin α2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target.",

keywords = "CD49b, Integrin α2, Molecular mechanisms, Regulation, Signaling",

author = "Valery Adorno-Cruz and Huiping Liu",

note = "Funding Information: We thank the Liu laboratory members, especially Andrew D. Hoffman, Erika Ramos, and Nurmaa K. Dashzeveg, for editing the manuscript. This manuscript is partially supported by the funds from the National Institutes of Health/National Cancer Institute (NIH/NCI) R00CA160638 (H.L.) and its Supplement for Diversity (V.A.), American Cancer Society 127951-RSG-15-025-01-CSM (H.L.), Susan G. Komen Foundation CCR15332826 (H.L.), and Department of Defense W81XWH-16-1-0021 (H.L.). Publisher Copyright: {\textcopyright} 2019 Chongqing Medical University",

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doi = "10.1016/j.gendis.2018.12.003",

language = "English (US)",

volume = "6",

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journal = "Genes and Diseases",

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AU - Liu, Huiping

N1 - Funding Information: We thank the Liu laboratory members, especially Andrew D. Hoffman, Erika Ramos, and Nurmaa K. Dashzeveg, for editing the manuscript. This manuscript is partially supported by the funds from the National Institutes of Health/National Cancer Institute (NIH/NCI) R00CA160638 (H.L.) and its Supplement for Diversity (V.A.), American Cancer Society 127951-RSG-15-025-01-CSM (H.L.), Susan G. Komen Foundation CCR15332826 (H.L.), and Department of Defense W81XWH-16-1-0021 (H.L.). Publisher Copyright: © 2019 Chongqing Medical University

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N2 - Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta (β) subunit with affinity for different extracellular membrane components. The integrin family includes 24 known members that actively regulate cellular growth, differentiation, and apoptosis. Each integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the family. As many reviews have covered the general integrin family in molecular and cellular studies in life science, this review will focus on the specific regulation, function, and signaling of integrin α2 subunit (CD49b, VLA-2; encoded by the gene ITGA2) in partnership with β1 (CD29) subunit in normal and cancer cells. Its roles in cell adhesion, cell motility, angiogenesis, stemness, and immune/blood cell regulations are discussed. The pivotal role of integrin α2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target.

AB - Integrins are cell adhesion molecules that are composed of an alpha (α) subunit and a beta (β) subunit with affinity for different extracellular membrane components. The integrin family includes 24 known members that actively regulate cellular growth, differentiation, and apoptosis. Each integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the family. As many reviews have covered the general integrin family in molecular and cellular studies in life science, this review will focus on the specific regulation, function, and signaling of integrin α2 subunit (CD49b, VLA-2; encoded by the gene ITGA2) in partnership with β1 (CD29) subunit in normal and cancer cells. Its roles in cell adhesion, cell motility, angiogenesis, stemness, and immune/blood cell regulations are discussed. The pivotal role of integrin α2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target.

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KW - Signaling

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Regulation and functions of integrin α2 in cell adhesion and disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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