Regulation of 5-Hydroxymethylcytosine Distribution by the TET Enzymes

John Z. Cao, Anastasia E. Hains, Lucy A. Godley*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

5-Hydroxymethylcytosine (5-hmC) has a critical role in the epigenetic regulation of many cellular processes, including differentiation, cytokine responses, and memory formation. This modified base is generated by the TET enzymes through oxidizing 5-methylcytosine and can be further oxidized to 5-formylcytosine and 5-carboxylcytosine. The level and distribution of 5-hmC in the genome is tightly controlled through transcription of TET genes, post-translational modifications on the TET enzymes, and various interacting partners of TET enzymes. Deregulation of 5-hmC is often found in pathological conditions and plays crucial roles in disease progression. This chapter will discuss recent findings regarding 5-hmC functions, TET proteins, and their gene regulations, as well as their relationships to cancer.

Original languageEnglish (US)
Title of host publicationRNA Technologies
PublisherSpringer Science and Business Media Deutschland GmbH
Pages229-263
Number of pages35
DOIs
StatePublished - 2019

Publication series

NameRNA Technologies
ISSN (Print)2197-9731
ISSN (Electronic)2197-9758

Keywords

  • 5-Hydroxymethylcytosine
  • 5-Methylcytosine
  • CpG
  • Demethylation
  • TET enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Biochemistry, medical

Fingerprint

Dive into the research topics of 'Regulation of 5-Hydroxymethylcytosine Distribution by the TET Enzymes'. Together they form a unique fingerprint.

Cite this