@inbook{32e03befd4624bff8205f8f62c3542e3,
title = "Regulation of 5-Hydroxymethylcytosine Distribution by the TET Enzymes",
abstract = "5-Hydroxymethylcytosine (5-hmC) has a critical role in the epigenetic regulation of many cellular processes, including differentiation, cytokine responses, and memory formation. This modified base is generated by the TET enzymes through oxidizing 5-methylcytosine and can be further oxidized to 5-formylcytosine and 5-carboxylcytosine. The level and distribution of 5-hmC in the genome is tightly controlled through transcription of TET genes, post-translational modifications on the TET enzymes, and various interacting partners of TET enzymes. Deregulation of 5-hmC is often found in pathological conditions and plays crucial roles in disease progression. This chapter will discuss recent findings regarding 5-hmC functions, TET proteins, and their gene regulations, as well as their relationships to cancer.",
keywords = "5-Hydroxymethylcytosine, 5-Methylcytosine, CpG, Demethylation, TET enzymes",
author = "Cao, {John Z.} and Hains, {Anastasia E.} and Godley, {Lucy A.}",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",
year = "2019",
doi = "10.1007/978-3-030-14792-1_10",
language = "English (US)",
series = "RNA Technologies",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "229--263",
booktitle = "RNA Technologies",
address = "Germany",
}