Neuroblastoma X glioma NG108-15 hybrid cells exposed to N 6,O 2'-dibutyryladenosine 3':5'-cyclic monophosphate for several days release [ 3H]acetylcholine in response to serotonin, prostaglandin F(2α), KCl, or veratridine. NG108-15 cells grown in the absence of dibutyryl cyclic AMP do not respond to an excitatory stimulus by releasing [ 3H]acetylcholine but can be shifted to a responsive state by treatment with dibutyryl cyclic AMP. Thus, the reactions that are required for acetylcholine release can be regulated in NG108-15 cells, thereby regulating the ability of cells to form synapses and the efficiency of synaptic communication.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - 1978|
ASJC Scopus subject areas