Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells

R. McGee, P. Simpson, C. Christian, M. Mata, P. Nelson, M. Nirenberg

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Neuroblastoma X glioma NG108-15 hybrid cells exposed to N 6,O 2'-dibutyryladenosine 3':5'-cyclic monophosphate for several days release [ 3H]acetylcholine in response to serotonin, prostaglandin F(2α), KCl, or veratridine. NG108-15 cells grown in the absence of dibutyryl cyclic AMP do not respond to an excitatory stimulus by releasing [ 3H]acetylcholine but can be shifted to a responsive state by treatment with dibutyryl cyclic AMP. Thus, the reactions that are required for acetylcholine release can be regulated in NG108-15 cells, thereby regulating the ability of cells to form synapses and the efficiency of synaptic communication.

Original languageEnglish (US)
Pages (from-to)1314-1318
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number3
DOIs
StatePublished - 1978

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