We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.
- Neuronal signaling
- Voltage-dependent Ca currents
ASJC Scopus subject areas
- Immunology and Allergy
- Clinical Neurology