TY - JOUR
T1 - Regulation of calcium currents by chemokines and their receptors
AU - Oh, Seog Bae
AU - Endoh, Takayuki
AU - Simen, Arthur A.
AU - Ren, Dongjun
AU - Miller, Richard J.
N1 - Funding Information:
This work was supported by grants from the NIH DA02121, DA13141, MH40165, NS33826, DK44840 and NS21442 to RJM. SBO was supported in part by postdoctoral fellowships program from Korea Science and Engineering Foundation. We would like to thank Dr. Pat Gray of ICOS for the generous supply of CCR4 constructs and MDC used in these studies.
PY - 2002
Y1 - 2002
N2 - We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.
AB - We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.
KW - Chemokines
KW - Neuronal signaling
KW - Voltage-dependent Ca currents
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U2 - 10.1016/S0165-5728(01)00485-4
DO - 10.1016/S0165-5728(01)00485-4
M3 - Article
C2 - 11880151
AN - SCOPUS:0036184216
SN - 0165-5728
VL - 123
SP - 66
EP - 75
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -