Regulation of calcium currents by chemokines and their receptors

Seog Bae Oh, Takayuki Endoh, Arthur A. Simen, Dongjun Ren, Richard J Miller*

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.

Original languageEnglish (US)
Pages (from-to)66-75
Number of pages10
JournalJournal of Neuroimmunology
Volume123
Issue number1-2
DOIs
StatePublished - Mar 14 2002

Keywords

  • Chemokines
  • Neuronal signaling
  • Voltage-dependent Ca currents

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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