Regulation of calcium currents by chemokines and their receptors

Seog Bae Oh; Takayuki Endoh; Arthur A. Simen; Dongjun Ren; Richard J. Miller

doi:10.1016/S0165-5728(01)00485-4

Regulation of calcium currents by chemokines and their receptors

Seog Bae Oh, Takayuki Endoh, Arthur A. Simen, Dongjun Ren, Richard J. Miller^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We investigated the modulation of voltage dependent Ca²⁺ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the I_Ba in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The I_Ba inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the I_Ba in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca²⁺ currents.

Original language	English (US)
Pages (from-to)	66-75
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	123
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(01)00485-4
State	Published - 2002

Funding

This work was supported by grants from the NIH DA02121, DA13141, MH40165, NS33826, DK44840 and NS21442 to RJM. SBO was supported in part by postdoctoral fellowships program from Korea Science and Engineering Foundation. We would like to thank Dr. Pat Gray of ICOS for the generous supply of CCR4 constructs and MDC used in these studies.

Keywords

Chemokines
Neuronal signaling
Voltage-dependent Ca currents

ASJC Scopus subject areas

Clinical Neurology
Neurology
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-5728(01)00485-4

Cite this

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title = "Regulation of calcium currents by chemokines and their receptors",

abstract = "We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.",

keywords = "Chemokines, Neuronal signaling, Voltage-dependent Ca currents",

author = "Oh, {Seog Bae} and Takayuki Endoh and Simen, {Arthur A.} and Dongjun Ren and Miller, {Richard J.}",

note = "Funding Information: This work was supported by grants from the NIH DA02121, DA13141, MH40165, NS33826, DK44840 and NS21442 to RJM. SBO was supported in part by postdoctoral fellowships program from Korea Science and Engineering Foundation. We would like to thank Dr. Pat Gray of ICOS for the generous supply of CCR4 constructs and MDC used in these studies.",

year = "2002",

doi = "10.1016/S0165-5728(01)00485-4",

language = "English (US)",

volume = "123",

pages = "66--75",

journal = "Journal of Neuroimmunology",

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T1 - Regulation of calcium currents by chemokines and their receptors

AU - Oh, Seog Bae

AU - Endoh, Takayuki

AU - Simen, Arthur A.

AU - Ren, Dongjun

AU - Miller, Richard J.

N1 - Funding Information: This work was supported by grants from the NIH DA02121, DA13141, MH40165, NS33826, DK44840 and NS21442 to RJM. SBO was supported in part by postdoctoral fellowships program from Korea Science and Engineering Foundation. We would like to thank Dr. Pat Gray of ICOS for the generous supply of CCR4 constructs and MDC used in these studies.

PY - 2002

Y1 - 2002

N2 - We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.

AB - We investigated the modulation of voltage dependent Ca2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α, RANTES and MDC inhibited the IBa in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The IBa inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the IBa in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca2+ currents.

KW - Chemokines

KW - Neuronal signaling

KW - Voltage-dependent Ca currents

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U2 - 10.1016/S0165-5728(01)00485-4

DO - 10.1016/S0165-5728(01)00485-4

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AN - SCOPUS:0036184216

SN - 0165-5728

VL - 123

SP - 66

EP - 75

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Regulation of calcium currents by chemokines and their receptors

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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