Regulation of cell function by extracellular matrix

H. William Schnaper*, Hynda K. Kleinman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a significant role in regulating the behavior of cells. Matrix proteins engender changes in cell shape and movement, bind growth factors, and facilitate cell-cell and cell-matrix interactions. Matrix-induced differentiation results from multiple stimuli that include: tensile forces on the cell, cytokine- or growth factor-mediated stimulation, and interaction with bioactive domains of matrix glycoproteins. Because these signals are important determinants of cell behavior, pharmacological manipulation of cell-matrix interactions may offer a valuable new approach to disease treatment.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalPediatric Nephrology
Volume7
Issue number1
DOIs
StatePublished - Feb 1993

Keywords

  • Basement membrane
  • Cell-matrix interactions
  • Extracellular matrix
  • Laminin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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