Regulation of desmosome assembly and adhesion

Taofei Yin, Kathleen J. Green

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.

Original languageEnglish (US)
Pages (from-to)665-677
Number of pages13
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number6 SPEC. ISS.
DOIs
StatePublished - Dec 2004

Keywords

  • Armadillo protein
  • Cadherin
  • Junction

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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