Regulation of desmosome assembly and adhesion

Taofei Yin; Kathleen J. Green

doi:10.1016/j.semcdb.2004.09.005

Regulation of desmosome assembly and adhesion

Taofei Yin, Kathleen J. Green

Pathology

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.

Original language	English (US)
Pages (from-to)	665-677
Number of pages	13
Journal	Seminars in Cell and Developmental Biology
Volume	15
Issue number	6 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.semcdb.2004.09.005
State	Published - Dec 2004

Keywords

Armadillo protein
Cadherin
Junction

ASJC Scopus subject areas

Cell Biology
Developmental Biology

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10.1016/j.semcdb.2004.09.005

Cite this

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title = "Regulation of desmosome assembly and adhesion",

abstract = "Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.",

keywords = "Armadillo protein, Cadherin, Junction",

author = "Taofei Yin and Green, {Kathleen J.}",

note = "Funding Information: The authors would like to thank S. Getsios, L. Godsel and A. Kowalczyk for helpful discussion and critically reading this manuscript. Work in the authors{\textquoteright} lab is supported by NIH grants R01AR41836, R01AR43380, and project #4 of P01 DE12328. ",

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T1 - Regulation of desmosome assembly and adhesion

AU - Yin, Taofei

AU - Green, Kathleen J.

N1 - Funding Information: The authors would like to thank S. Getsios, L. Godsel and A. Kowalczyk for helpful discussion and critically reading this manuscript. Work in the authors’ lab is supported by NIH grants R01AR41836, R01AR43380, and project #4 of P01 DE12328.

PY - 2004/12

Y1 - 2004/12

N2 - Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.

AB - Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.

KW - Armadillo protein

KW - Cadherin

KW - Junction

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Regulation of desmosome assembly and adhesion

Abstract

Keywords

ASJC Scopus subject areas

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