Regulation of Foxo-dependent transcription by post-translational modifications

Marco Boccitto*, Robert G. Kalb

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo.

Original languageEnglish (US)
Pages (from-to)1303-1310
Number of pages8
JournalCurrent Drug Targets
Volume12
Issue number9
DOIs
StatePublished - Aug 2011

Keywords

  • Acetylation
  • Foxo
  • Phosphorylation
  • Post-translational modifications
  • Ubiquitination

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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