Regulation of glycosyltransferase genes in apoptotic breast cancer cells induced by l-PPMP and cisplatin

Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks, James R. Johnson, Joseph Moskal, Manju Basu, Sipra Banerjee, Subhash Basu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The process of apoptosis is usually triggered by various signals that may have originated extracellularly or intracellularly [1] (Fig. 33.1). The apoptotic signaling initiating from an extracellular source is called an "extrinsic pathway" [2]. The extrinsic apoptotic inducers could be small molecules, such as nitric oxide, hormones such as estrogen [3], or cytokines such as a tumor necrosis factor (TNF-alpha) [4-7]. The death receptor (DR) family plays the most crucial role in transducing the extracellular apoptotic signal to the cytosol apoptotic machinery [8]. The DR family is part of the TNF-receptor superfamily and is usually activated by several cytokines called death ligands. Eight members of the DR family have been identified to date. Although the names of the DRs have varied since the initial discovery of each member, the most common names for each have now been accepted. These are DR1-TNFR1, DR2-CD95, DR3-TRAMP, DR4-TRAILR1, DR5-TRAILR2, DR-6, EDAR, and NGF-R.

Original languageEnglish (US)
Title of host publicationThe Molecular Immunology of Complex Carbohydrates-3
EditorsAlbert Wu
Pages621-642
Number of pages22
DOIs
StatePublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume705
ISSN (Print)0065-2598

Keywords

  • Apoptosis
  • Breast carcinomas
  • Cisplatin
  • DNA microarray
  • GalT
  • Gangliosides
  • GlcT
  • Glycolipids
  • Glycosyltransferases
  • SA-LeX
  • SAT
  • l-PPMP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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