@inproceedings{34625a07416c409cbf6ad4c75b19399b,
title = "Regulation of glycosyltransferase genes in apoptotic breast cancer cells induced by l-PPMP and cisplatin",
abstract = "The process of apoptosis is usually triggered by various signals that may have originated extracellularly or intracellularly [1] (Fig. 33.1). The apoptotic signaling initiating from an extracellular source is called an {"}extrinsic pathway{"} [2]. The extrinsic apoptotic inducers could be small molecules, such as nitric oxide, hormones such as estrogen [3], or cytokines such as a tumor necrosis factor (TNF-alpha) [4-7]. The death receptor (DR) family plays the most crucial role in transducing the extracellular apoptotic signal to the cytosol apoptotic machinery [8]. The DR family is part of the TNF-receptor superfamily and is usually activated by several cytokines called death ligands. Eight members of the DR family have been identified to date. Although the names of the DRs have varied since the initial discovery of each member, the most common names for each have now been accepted. These are DR1-TNFR1, DR2-CD95, DR3-TRAMP, DR4-TRAILR1, DR5-TRAILR2, DR-6, EDAR, and NGF-R.",
keywords = "Apoptosis, Breast carcinomas, Cisplatin, DNA microarray, GalT, Gangliosides, GlcT, Glycolipids, Glycosyltransferases, SA-LeX, SAT, l-PPMP",
author = "Rui Ma and Hopp, {Elizabeth A.} and Decker, {N. Matthew} and Audrey Loucks and Johnson, {James R.} and Joseph Moskal and Manju Basu and Sipra Banerjee and Subhash Basu",
note = "Funding Information: This article was written based on research supported by grants NS-18005 (NIMDS) and CA-14764 (NCI) and grants-in-aid from the Bayer Corporation (Elkhart, Indiana) and the Coleman Foundation (Chicago, IL) to Subhash Basu. We are grateful to Dr. Surendra Gupta of the American Radiolabeled Corporation, St. Louis, MO, and Sudip Basu of the Moraveck Chemicals Corporation, Brea, CA, for providing us with the radioactive precursor chemicals needed for this project. We are thankful to Professor Bradley Smith of the University of Notre Dame for his newly synthesized PSS-380 and AKS-0 dyes that we used for our phosphatidylserine-binding and mitochondrial-membrane-scrambling studies. Our special thanks to Professor Jen-ichi Inokuchi of Hokkaido University, Hokkaido, Japan, for providing us with gift samples of chemically synthesized l -/ d -PPMP and l -/ d -PDMP, which were used as apoptotic agents. We gratefully acknowledge the editorial help of Ms. Dorisanne Nielsen, Miss Elizabeth Laughran, and Christopher Thomas during the preparation of this manuscript.",
year = "2011",
doi = "10.1007/978-1-4419-7877-6_33",
language = "English (US)",
isbn = "9781441978769",
series = "Advances in Experimental Medicine and Biology",
pages = "621--642",
editor = "Albert Wu",
booktitle = "The Molecular Immunology of Complex Carbohydrates-3",
}
