@article{498c8caffc2047b089f8144d3adb7fcd,
title = "Regulation of IgE by T follicular helper cells",
abstract = "Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the cellular pathway to high-affinity IgE is typically through sequential switching of IgG B cells. Further, in contrast to the previously held paradigm that a subset of CD4+ T cells called Th2 cells promotes IgE responses, recent studies suggest that T follicular helper cells are crucial for inducing anaphylactic IgE. Here we discuss recent studies that have enabled us to understand the nature, induction, and regulation of this enigmatic antibody isotype in allergic sensitization.",
keywords = "Allergy, Anaphylaxis, IgE, Tfh cells, Th2 cells",
author = "Uthaman Gowthaman and Chen, {Jennifer S.} and Eisenbarth, {Stephanie C.}",
note = "Funding Information: U.G. and S.C.E. conceptualized the review. U.G., J.C., and S.C.E. wrote the manuscript and designed the figures. All authors contributed to manuscript revision, read, and approved the submitted version. We thank Adam Williams (The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA), Jake Gertie (Yale University, New Haven, CT, USA) for their comments and critical reading of the manuscript, and members of the Eisenbarth Laboratory for helpful discussions. This work was supported by Food Allergy Research and Education Ira and Diana Riklis Family Research Award in Food Allergy, R01 AI136942, and R01 AI108829. Funding Information: We thank Adam Williams (The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA), Jake Gertie (Yale University, New Haven, CT, USA) for their comments and critical reading of the manuscript, and members of the Eisenbarth Laboratory for helpful discussions. This work was supported by Food Allergy Research and Education Ira and Diana Riklis Family Research Award in Food Allergy, R01 AI136942, and R01 AI108829. Publisher Copyright: {\textcopyright}2020 Society for Leukocyte Biology",
year = "2020",
month = mar,
day = "1",
doi = "10.1002/JLB.3RI1219-425R",
language = "English (US)",
volume = "107",
pages = "409--418",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "3",
}