Regulation of immune responses by I-J gene products. V. Heterogeneity of I-J gene products as detected by anti-I-J monoclonal antibodies

C. Waltenbaugh, H. Y. Lei

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The products of I-region genes of the murine major histocompatibility complex (H-2) are intimately involved in the regulation of immune responses. In a number of antigen systems, suppressor T (Ts) cells and their factors (TsF) bear determinants of gene(s) that map to the I-J subregion of the H-2 complex. Suppression in one such system, poly(Glu50Tyr50)-(GT), involves the interaction of multiple Ts subsets. Three monoclonal I-J(k)-bearing GT-TsF have been identified that functionally differ from one another. We report the binding of these monoclonal GT-TsF to different anti-I-J(k) monoclonal antibody columns. We find that these anti-I-J(k) monoclonal antibodies display differing degrees of efficiency of GT-TsF binding. These data suggest a greater degree of heterogeneity of I-J(k) gene products than has been proposed before.

Original languageEnglish (US)
Pages (from-to)1730-1734
Number of pages5
JournalJournal of Immunology
Volume133
Issue number4
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Immunology

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