Regulation of interferon-dependent mRNA translation of target genes

Barbara Kroczynska; Swarna Mehrotra; Ahmet Dirim Arslan; Surinder Kaur; Leonidas C. Platanias

doi:10.1089/jir.2013.0148

Regulation of interferon-dependent mRNA translation of target genes

Barbara Kroczynska^*, Swarna Mehrotra, Ahmet Dirim Arslan, Surinder Kaur, Leonidas C. Platanias

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.

Original language	English (US)
Pages (from-to)	289-296
Number of pages	8
Journal	Journal of Interferon and Cytokine Research
Volume	34
Issue number	4
DOIs	https://doi.org/10.1089/jir.2013.0148
State	Published - Apr 1 2014

ASJC Scopus subject areas

Virology
Cell Biology
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1089/jir.2013.0148

Cite this

@article{0d67aff1042e48cd9753c62f6caaaf05,

title = "Regulation of interferon-dependent mRNA translation of target genes",

abstract = "Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.",

author = "Barbara Kroczynska and Swarna Mehrotra and Arslan, {Ahmet Dirim} and Surinder Kaur and Platanias, {Leonidas C.}",

year = "2014",

month = apr,

day = "1",

doi = "10.1089/jir.2013.0148",

language = "English (US)",

volume = "34",

pages = "289--296",

journal = "Journal of Interferon and Cytokine Research",

issn = "1079-9907",

publisher = "Mary Ann Liebert Inc.",

number = "4",

}

TY - JOUR

T1 - Regulation of interferon-dependent mRNA translation of target genes

AU - Kroczynska, Barbara

AU - Mehrotra, Swarna

AU - Arslan, Ahmet Dirim

AU - Kaur, Surinder

AU - Platanias, Leonidas C.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.

AB - Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.

UR - http://www.scopus.com/inward/record.url?scp=84898762741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898762741&partnerID=8YFLogxK

U2 - 10.1089/jir.2013.0148

DO - 10.1089/jir.2013.0148

M3 - Review article

C2 - 24559173

AN - SCOPUS:84898762741

SN - 1079-9907

VL - 34

SP - 289

EP - 296

JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

IS - 4

ER -

Regulation of interferon-dependent mRNA translation of target genes

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this