Regulation of interferon-dependent mRNA translation of target genes

Barbara Kroczynska*, Swarna Mehrotra, Ahmet Dirim Arslan, Surinder Kaur, Leonidas C. Platanias

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalJournal of Interferon and Cytokine Research
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2014

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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