Regulation of low affinity neurotrophin receptor (p75NTR) by early growth response (Egr) transcriptional regulators

Xiaoguang Gao, Rebecca L. Daugherty, Warren G. Tourtellotte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The low affinity neurotrophin receptor p75NTR is a multifunctional receptor with important roles in neurotrophin signaling, axon outgrowth, and oligodendroglia and neuron survival. It is transcriptionally regulated with spatial and temporal precision during nervous system development, injury and regeneration. Very little is known about how p75NTR expression is dynamically regulated but it is likely to influence how p75NTR signals in particular cellular contexts. Here, we identify the early growth response (Egr) transcriptional regulators, Egr1 and Egr3, as direct modulators of p75NTR gene expression. Egr1 and Egr3 bind and transactivate the p75NTR promoter in vitro and in vivo, using distinct response elements on the p75NTR promoter. Consistent with these results, p75NTR expression is greatly diminished in muscle spindle stretch receptors and in peripheral nerve Schwann cells in Egr gene deficient mice. Taken together, the results elucidate a novel mechanism whereby Egr proteins can directly modulate p75NTR expression and signaling in vivo.

Original languageEnglish (US)
Pages (from-to)501-514
Number of pages14
JournalMolecular and Cellular Neuroscience
Volume36
Issue number4
DOIs
StatePublished - Dec 2007

Keywords

  • Development
  • Egr
  • Low affinity neurotrophin receptor
  • Transcriptional regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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