Regulation of microRNA expression: The hypoxic component

Ritu Kulshreshtha, Manuela Ferracin, Massimo Negrini, George A. Calin, Ramana V. Davuluri*, Mircea Ivan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.

Original languageEnglish (US)
Pages (from-to)1425-1430
Number of pages6
JournalCell Cycle
Volume6
Issue number12
StatePublished - Jun 15 2007
Externally publishedYes

Keywords

  • Cancer
  • Expression profiles
  • Hypoxia
  • microRNA
  • Regulation
  • Target genes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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