Regulation of micrornas in inflammation-associated colorectal cancer: A mechanistic approach

Sridhar Muthusami, Ilangovan Ramachandran*, Sneha Krishnamoorthy, Yuvaraj Sambandam, Satish Ramalingam, Lurdes Queimado, Gautam Chaudhuri, Ileng Kumaran Ramachandran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The development of colorectal cancer (CRC) is a multistage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn’s disease (CD) is often regarded as the initial trigger for the development of inflammation-associated CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC, through differential regulation of microRNAs (miRNAs/miRs). miRNAs can be oncogenic miRNAs (oncomiRs) or anti-oncomiRs/tumor suppressor miRNAs, and they play key roles during colorectal carcinogenesis. However, the functions and molecular mechanisms of regulation of miRNAs involved in inflammation-associated CRC are still anecdotal and largely unknown. Consolidating the published results and offering perspective solutions to circumvent CRC, the current review is focused on the role of miRNAs and their regulation in the development of CRC. We have also discussed the model systems adapted by researchers to delineate the role of miRNAs in inflammation-associated CRC.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Volume21
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Colitis-associated CRC (CAC)
  • Colorectal cancer (CRC)
  • Cytokines
  • Inflammation
  • Inflammation-associated CRC
  • Inflammatory bowel disease (IBD)
  • Interleukin (IL)
  • Metastasis
  • MicroRNA (miRNA/miR)
  • Nuclear factor (NF) kappa-lightchain-enhancer of activated B cells (NFκB)
  • Tumor necrosis factor (TNF)
  • Ulcerative colitis (UC)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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