Reguliatsiia sborki i razborki mikrotrubochek nukleotidami.

Translated title of the contribution: Regulation of microtubule assembly and disassembly by nucleotides

V. I. Gel'fand*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The role of nucleotides in microtubular assembly and disassembly has been reviewed. Two possible functions of GTP hydrolysis during assembly are discussed: (1) hydrolysis renders sensitivity to factor(s) regulating microtubule depolymerization; (2) the energy of GTP hydrolysis is utilized for the subunit flow from one end of the microtubule to the other. In the second part of the review, experiments are considered showing that microtubular disassembly takes place in the cells only in the presence of ATP, and, therefore, this process is regulated via some ATP-dependent mechanism (most probably, phosphorylation of microtubule-associated proteins).

Translated title of the contributionRegulation of microtubule assembly and disassembly by nucleotides
Original languageRussian
Pages (from-to)362-370
Number of pages9
Issue number4
StatePublished - Apr 1 1984

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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