Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor

Stephen J. Galli*, Mindy Tsai, Barry K. Wershil, See Ying Tama, John J. Costa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by FceRIdependent mechanisms. These findings raise several clinical issues and, in some cases, point to potentially significant therapeutic opportunities.

Original languageEnglish (US)
Pages (from-to)51-53
Number of pages3
JournalInternational archives of allergy and immunology
Volume107
Issue number1-3
DOIs
StatePublished - Jan 1 1995

Keywords

  • Allergy
  • Anaphylaxis
  • Apoptosis
  • Bcl-2
  • C -kit
  • IgE antibody
  • Mast cells
  • Mast-cell-deficient mice
  • Mastocytosis
  • Proto-oncogenes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor'. Together they form a unique fingerprint.

Cite this