Regulation of organismal proteostasis by transcellular chaperone signaling

Patricija Van Oosten-Hawle, Robert S. Porter, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


A major challenge for metazoans is to ensure that different tissues, each expressing distinctive proteomes, are nevertheless well protected at an organismal level from proteotoxic stress. We show that expression of endogenous metastable proteins in muscle cells, which rely on chaperones for proper folding, induces a systemic stress response throughout multiple tissues of C. elegans. Suppression of misfolding in muscle cells can be achieved not only by enhanced expression of HSP90 in muscle cells but as effectively by elevated expression of HSP90 in intestine or neuronal cells. This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4. This transcellular chaperone signaling response maintains organismal proteostasis when challenged by a local tissue imbalance in folding and provides the basis for organismal stress-sensing surveillance.

Original languageEnglish (US)
Pages (from-to)1366
Number of pages1
Issue number6
StatePublished - Jun 6 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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