Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

Zhuan Zhou, Chao Jing, Liyong Zhang, Fujita Takeo, Hyun Kim, Yi Huang, Zhihua Liu, Yong Wan*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Abrogated Rad17-APC axis is involved in genome instability and tumorigenesis. Results: Proteolytic regulation of Rad17 is involved in breast tumorigenesis and could be targeted for chemosensitization. Conclusion: Regulation of Rad17 turnover is important in the maintenance of genome stability and carcinogenesis. Significance: Demonstration of impact of Rad17 turnover regulation in genome stability, tumorigenesis, and chemosensitization.

Original languageEnglish (US)
Pages (from-to)18134-18145
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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