Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

Zhuan Zhou; Chao Jing; Liyong Zhang; Fujita Takeo; Hyun Kim; Yi Huang; Zhihua Liu; Yong Wan

doi:10.1074/jbc.M113.456962

Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

Zhuan Zhou, Chao Jing, Liyong Zhang, Fujita Takeo, Hyun Kim, Yi Huang, Zhihua Liu, Yong Wan^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Abrogated Rad17-APC axis is involved in genome instability and tumorigenesis. Results: Proteolytic regulation of Rad17 is involved in breast tumorigenesis and could be targeted for chemosensitization. Conclusion: Regulation of Rad17 turnover is important in the maintenance of genome stability and carcinogenesis. Significance: Demonstration of impact of Rad17 turnover regulation in genome stability, tumorigenesis, and chemosensitization.

Original language	English (US)
Pages (from-to)	18134-18145
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	25
DOIs	https://doi.org/10.1074/jbc.M113.456962
State	Published - Jun 21 2013

Funding

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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10.1074/jbc.M113.456962

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title = "Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment",

abstract = "Background: Abrogated Rad17-APC axis is involved in genome instability and tumorigenesis. Results: Proteolytic regulation of Rad17 is involved in breast tumorigenesis and could be targeted for chemosensitization. Conclusion: Regulation of Rad17 turnover is important in the maintenance of genome stability and carcinogenesis. Significance: Demonstration of impact of Rad17 turnover regulation in genome stability, tumorigenesis, and chemosensitization.",

author = "Zhuan Zhou and Chao Jing and Liyong Zhang and Fujita Takeo and Hyun Kim and Yi Huang and Zhihua Liu and Yong Wan",

year = "2013",

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doi = "10.1074/jbc.M113.456962",

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pages = "18134--18145",

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T1 - Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

AU - Zhou, Zhuan

AU - Jing, Chao

AU - Zhang, Liyong

AU - Takeo, Fujita

AU - Kim, Hyun

AU - Huang, Yi

AU - Liu, Zhihua

AU - Wan, Yong

PY - 2013/6/21

Y1 - 2013/6/21

N2 - Background: Abrogated Rad17-APC axis is involved in genome instability and tumorigenesis. Results: Proteolytic regulation of Rad17 is involved in breast tumorigenesis and could be targeted for chemosensitization. Conclusion: Regulation of Rad17 turnover is important in the maintenance of genome stability and carcinogenesis. Significance: Demonstration of impact of Rad17 turnover regulation in genome stability, tumorigenesis, and chemosensitization.

AB - Background: Abrogated Rad17-APC axis is involved in genome instability and tumorigenesis. Results: Proteolytic regulation of Rad17 is involved in breast tumorigenesis and could be targeted for chemosensitization. Conclusion: Regulation of Rad17 turnover is important in the maintenance of genome stability and carcinogenesis. Significance: Demonstration of impact of Rad17 turnover regulation in genome stability, tumorigenesis, and chemosensitization.

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EP - 18145

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

Abstract

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