Regulation of Rat Heart Lipoprotein Lipase Activity During Cold Exposure (38212)

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Abstract

Starved thyroidectomized, ad-renalectomized, adrenal-demedullated and sham operated rats were exposed to 4° for 3 hr and their heart lipoprotein lipase activities compared to those of animals maintained at room temperature. The lipoprotein lipase activity in the hearts of the thyroidectomized rats was comparable to that of the sham operated animals when expressed as units/heart. The enzyme activities in the hearts of the adrenalectomized and adrenal-demedullated rats were about 50% lower than those of the controls. In all animals, exposure to cold temperature induced significant increases in the myo-cardial lipoprotein lipase activity. In normal rats this effect could not be reversed by the administration of insulin. It is concluded that the increases in lipoprotein lipase activity in the hearts of rats exposed to cold temperatures are not dependent on adrenal and thyroid hormones.

Original languageEnglish (US)
Pages (from-to)890-893
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number3
DOIs
StatePublished - Jul 1974

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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