@article{42e54ac9ad5e409c9a5314a98a5c8e0e,
title = "Regulation of redox balance in cancer and T cells",
abstract = "Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death. Therefore, regulation of redox homeostasis is essential for ROS-dependent signaling that does not incur cellular damage. Cells achieve this optimal balance by coordinating ROS production and elimination. In this Minireview, we discuss the mechanisms by which proliferating cancer and T cells maintain a carefully controlled redox balance. Greater insight into such redox biology may enable precisely targeted manipulation of ROS for effective medical therapies against cancer or immunological disorders.",
author = "Hyewon Kong and Chandel, {Navdeep S.}",
note = "Funding Information: This work was supported in part by National Institute of Health Grants 5R35CA197532-02, 5P01AG049665-03, and 5P01HL071643-13 (to N. S. C.). This is the second article in the Thematic Minireview Series “Redox metabolism and signaling.” The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. 1 Supported by National Institute of Health Pre-doctoral Training Grant T32 CA9560. We apologize for any references not cited due to space limitations. Funding Information: This work was supported in part by National Institute of Health Grants 5R35CA197532-02, 5P01AG049665-03, and 5P01HL071643-13 (to N. S. C.). This is the second article in the Thematic Minireview Series “Redox metab-olism and signaling.” The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the respon-sibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 by The American Society for Biochemistry and Molecular Biology, Inc.",
year = "2018",
month = may,
day = "18",
doi = "10.1074/jbc.TM117.000257",
language = "English (US)",
volume = "293",
pages = "7499--7507",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "20",
}
